Search for dissertations about: "Mitsunobu"
Showing result 1 - 5 of 6 swedish dissertations containing the word Mitsunobu.
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1. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides
Abstract : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. READ MORE
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2. Expanding the H-phosphonate and H-phosphonothioate chemistry towards biologically important phosphate analogs
Abstract : This thesis focuses on chemical transformations of H-phosphonate and H-phosphonothioate and can be divided in two parts. The first part, is devoted to the development of the palladium-catalyzed P-C bond formation. Both mechanistic and synthetic studies of the transformations have been performed. READ MORE
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3. Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A
Abstract : In order to find suitable stable vaccine candidates against Neisseria meningitidis group A, several structures related to the capsular polysaccharide have been synthesised. The first part of the thesis describes the synthesis of C-phosphonate analogues starting from glucose. READ MORE
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4. Synthesis of Potential Inhibitors Against HIV
Abstract : This thesis describes the syntheses of various potential inhibitors of HIV, e.g. some 3´-hydroxymethyl-substituted carbocyclic nucleoside analogues as reverse transcriptase inhibitors and some symmetry-based peptidomimetics as protease inhibitors. READ MORE
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5. Synthesis of Carbohydrate Mimics and Development of a Carbohydrate Epimerisation Method
Abstract : In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5. READ MORE
