Search for dissertations about: "Molecular life science"

Showing result 1 - 5 of 179 swedish dissertations containing the words Molecular life science.

  2. 1. Touching the Essence of Life : Haptic Virtual Proteins for Learning

    Author : Petter Bivall; Anders Ynnerman; Lena A. E. Tibell; Matthew D. Cooper; Miriam Reiner; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Haptics; Educational Research; Biomolecular Education; Life Science; JND; Just Noticeable Difference; Protein-ligand Docking; Haptic docking; Visualization; Haptic Transfer Functions; Volume Data Haptics; History Dependent Transfer Function; Log file analysis; Molecular Recognition; Force Feedback; Virtual Reality; Other information technology; Övrig informationsteknik;

    Abstract : This dissertation presents research in the development and use of a multi-modal visual and haptic virtual model in higher education. The model, named Chemical Force Feedback (CFF), represents molecular recognition through the example of protein-ligand docking, and enables students to simultaneously see and feel representations of the protein and ligand molecules and their force interactions. READ MORE

  4. 2. New Molecular Approaches to Glioblastoma Therapy

    Author : Sathishkumar Baskaran; Sven Nelander; Karin Forsberg Nilsson; Silvia Marino; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; GBM; ZBTB16; PLZF; Heterogeneity; Proteasome inhibitors; Bortezomib; Pterostilbene; drug combinations; Oncology; Onkologi; Biological Research on Drug Dependence; Biologisk beroendeforskning; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Abstract : Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than 50 years of age. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. The median life expectancy of patients is only between 12 to 15 months after receiving current treatment regimes. READ MORE

  5. 3. Dried blood sampling and digital readout to advance molecular diagnostics

    Author : Johan Björkesten; Ulf Landegren; Björn Högberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular diagnostics; dried blood sample; DBS; digital readout; digital enumeration; DNA detection methods; proximity extension assay; protein stability; genotyping; rare mutations; cell free DNA; multiplex protein measurement.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A drastically increased capacity to measure large sets of molecular features in numerous patient samples in great detail will be required to fulfill the vision of precision medicine and wellness, which may characterize molecular diagnostics in the 21st century. Also sampling procedures need a renaissance to permit continuous sampling at population levels at reasonable cost. READ MORE

  6. 4. Synthesis of nucleotide, peptide and lipid containing molecular tools for life science studies

    Author : Esmail Yousefi Salakdeh; J.H. Van Boom; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Abstract : This thesis is based on five parts. The first and second chapters describes two synthetic routes, employing different protecting group strategies for synthesis of uridine 3'-(ethyl, 2-ethoxyethyl, 2-chloroethyl, 2,2-dichloroethyl and 2,2,2-trichloroethyl) phosphate. READ MORE

  7. 5. Making Visible the Proximity Between Proteins

    Author : Carl-Magnus Clausson; Ola Söderberg; Jens Coorssen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Proximity ligation assay; In situ PLA; rolling circle amplification; protein interaction; protein-protein interaction; in situ; single cell; single molecule; protein complex; antibody; cancer; tissue section; microscopy; image analysis; system biology; multiplex; dynamic range; methods development; systems biology; Molekylär medicin; Molecular Medicine;

    Abstract : Genomic DNA is the template of life - the entity which is characterized by a self-sustaining anatomical development, regulated signaling processes, the ability to reproduce and to respond to stimuli. Through what is classically known as the central dogma, the genome is transcribed into mRNA, which in turn is translated into proteins. READ MORE