Search for dissertations about: "Multivariate analysis in pharmaceutical"

Showing result 1 - 5 of 27 swedish dissertations containing the words Multivariate analysis in pharmaceutical.

  2. 1. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

    Author : Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

    Abstract : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. READ MORE

  4. 2. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach

    Author : Thomas Österberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE

  5. 3. Terahertz sensing for pharmaceutical applications

    Author : Anis Moradikouchi; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; frequency domain spectroscopy; terahertz sensing; multivariate analysis; Pharmaceutical; radar; porosity; powders; API content; tablets; powder flow characterization; tablet density;

    Abstract : Pharmaceutical tablets are manufactured through the compaction of powder blends or granules in batch or continuous processes. In continuous manufacturing, real-time assurance of quality becomes essential to ensure that the final product meets the quality standards approved by manufacturers and regulatory authorities. READ MORE

  6. 4. Solid state characterisation and compaction behaviour of pharmaceutical materials

    Author : Christina Gustafsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Solid-state; Tablet; Thermal analysis; Cellulose; Spectroscopy; NMR; NIR; FT-IR; Crystallinity; MVDA; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : In this thesis, factors important in tableting operations and for tablet properties have been studied and characterised by different spectroscopic techniques as well as by some more conventionally used particle characterisation techniques. The spectroscopic techniques solid-state NMR, FT-IR and NIR spectroscopy, proved to be valuable tools in the estimation of particle and tablet properties, offering both specificity and sensitivity in the measurements. READ MORE

  7. 5. Muscarinic receptors and urinary bladder selectivity : Properties that determine the organ selectivity of compounds

    Author : Staffan Sundquist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; bladder; muscarinic; receptor subtypes; smooth muscle; multivariate; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Urinary bladder contraction is mainly mediated by activation of muscarinic acetylcholine receptors (mAChR). Muscarinic antagonists are often effective in treatment of unstable bladder. The effectiveness of this treatment has often been limited by side effects as dry mouth. READ MORE