Search for dissertations about: "NAT2"

Showing result 1 - 5 of 8 swedish dissertations containing the word NAT2.

  2. 1. Pharmacogenetic analysis in sickness and in health - for better or for worse

    Author : Mia Wadelius; Uppsala universitet; []
    Keywords : Medical sciences; Pharmacogenetics; NAT2; CYP2D6; CYP2C19; CYP17; GSTP1; sulphasalazine; agranulocytosis; prostate cancer; pregnancy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. READ MORE

  4. 2. Importance of pharmacogenetic and environmental factors for variation in caffeine disposition : with special emphasis on CYP1A2, CYP2A6, NAT2 and XO

    Author : Natasa Djordjevic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inter-individual variation in response to drugs conveys considerable risk of either therapy failure or drug toxicity. Caffeine, as one of the most frequently used psychoactive substances in the world, is not an exception, and both lack of effects and adverse reactions have been observed after usual doses. READ MORE

  5. 3. Environmental and genetic factors in lung cancer : epidemiologocal and biomolecular studies focusing on nonsmokers

    Author : Fredrik Nyberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung cancer; case-control study; smoking misclassification; exposure misclassification; validation; bias; nonsmoker; smoking; environmental tobacco smoke; ETS; diet; biomarker; glutathione S transferase; GSTM1; N-acetyl transferase; NAT2; hypoxanthine-guanine phosphoribosiyl transferase; hprt; DNA; adducts;

    Abstract : Tobacco smoking is the major cause of lung cancer. Other risk factors include exposure to environmental tobacco smoke (ETS), dietary habits and genetic factors. When studying such risk factors, confounding from smoking presents a pervasive methodological problem. READ MORE

  6. 4. Targeting allelic loss in colorectal cancer

    Author : Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Abstract : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. READ MORE

  7. 5. Polyurethane - occupational exposure, biomarkers and symptoms

    Author : Margareta Littorin; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spray; polyurethane; nose; metabolites; lung function ; lower airways; inflammation; heat; glue; genetic polymorphism; di isocyanate; Antibodies; biomarkers; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin; symptoms;

    Abstract : Isocyanates may cause occupational asthma, rhinitis, and hypersensitivity pneumonitis. However, the mechanisms behind initiation of the disorders and the relations between exposure and effect are insufficiently elucidated. Means to biomonitor exposure and risk would be valuable. READ MORE