Search for dissertations about: "NATURAL SCIENCES Biology Cell and molecular biology Genetics"

Showing result 16 - 20 of 61 swedish dissertations containing the words NATURAL SCIENCES Biology Cell and molecular biology Genetics.

  2. 16. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

    Author : Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

    Abstract : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. READ MORE

  4. 17. Genetics of Two Mendelian Traits and Validation of Induced Pluripotent Stem Cell (iPSC) Technology for Disease Modeling

    Author : Doroteya Raykova; Niklas Dahl; Ann Nordgren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Disease modeling; Mendelian disorders; iPSC; Whole exome sequencing; Transcriptome sequencing; Medical Science; Medicinsk vetenskap;

    Abstract : Novel technologies for genome analysis have provided almost unlimited opportunities to uncover structural gene variants behind human disorders. Whole exome sequencing (WES) is especially useful for understanding rare Mendelian conditions, because it reduces the requirements for a priori clinical data, and can be applied on a small number of patients. READ MORE

  5. 18. Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies

    Author : Carina Cardemil; Peter Thomsen; Cecilia Larsson Wexell; Bente Brokstad Herlofson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Qntiresorptive agents; ovariectomised rat; osteoporosis; skeletal site; differences osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT; antiresorptive agents; ovariectomised rat; osteoporosis; skeletal site differences; osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT;

    Abstract : The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. READ MORE

  6. 19. Acetylation of polysaccharides in plant cell wall : with a focus on woody species

    Author : Prashant Mohan Pawar; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Plant cell wall in woody tissues is a complex matrix, which consists of cellulose, matrix polysaccharides and lignin. The matrix polysaccharides are substituted with acetyl group that are hypothesised to play important roles in determining properties of these polysaccharides. READ MORE

  7. 20. Host-parasite interactions in space and time

    Author : Franziska Hildebrandt; Johan Ankarklev; Volker T. Heussler; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; liver-stage infection; Toxoplasma; host-parasite interactions; spatial transcriptomics; single-cell omics; single-cell Dual-seq; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Unicellular parasites of the apicomplexan phylum have a considerable effect on global health and agriculture. Two prominent examples of this phylum include malaria causing parasites of the Plasmodium genus and the widely prevalent parasite Toxoplasma gondii. READ MORE