Search for dissertations about: "NF-kB"

Showing result 1 - 5 of 50 swedish dissertations containing the word NF-kB.

  2. 1. NF-kB in epidermal signal transduction and tumor development

    Author : Max van Hogerlinden; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology and epidermal tumor development are largely unknown. READ MORE

  4. 2. The immunomodulatory properties of C-Med 100 an extract of the plant Uncaria tomentosa

    Author : Christina Silver; Diabetes - immunovirologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; survival; proliferation; inhibition; NF-kB; Uncaria tomentosa; quinic acid;

    Abstract : Extracts from the bark of the vine Uncaria tomentosa have anti-inflammatory, antiviral, antimutagenic and antioxidant effects. In this study, we evaluate the effects of an Uncaria tomentosa extract, denoted C-Med 100, on the cellular level of the immune system both in vivo and in vitro. READ MORE

  5. 3. Regulation of lymphocyte activation and death

    Author : Hanna Lindgren; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; N-substituted benzamides; apoptosis; NF-kB; NFAT; T cells; CD40L; serology; transplantation; Immunologi; serologi;

    Abstract : T lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. READ MORE

  6. 4. The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses

    Author : Christina Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; CD28; costimulation; CD152; IL-2; NF-kB; AP-1; superantigen; Immunology; T cell; serologi;

    Abstract : T cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. READ MORE

  7. 5. Methods for Preclinical Evaluation of Cytotoxic Drugs : With Special Reference to the Cyanoguanidine CHS 828 and Hollow Fiber Method

    Author : Saadia Bashir Hassan; Elin Lindhagen; Rolf Larsson; Mats O Karlsson; Mustapha Hassan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; in vitro; in vivo; hollow fiber; models; NF-kB; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : The novel cyanoguanidine CHS 828 has shown promising antitumor activity in many in vitro and in vivo studies. The long-term 14 days in vitro hollow fiber cultures, where tumor cells from different tumor cell lines were cultured inside semipermeable fibers, were more resistant to CHS 828 and other cytotoxic drugs than the shorter-term 3 days cultures. READ MORE