Search for dissertations about: "NIDDM1I"

Found 3 swedish dissertations containing the word NIDDM1I.

  2. 1. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Author : Charlotte Granhall; Genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Abstract : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. READ MORE

  4. 2. Identification and characterization of candidate genes for type 2 diabetes in the GK rat

    Author : Hossein Fakhrai-Rad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 2 diabetes is a common multifactorial disorder with complex genetics, which presents with a heterogeneous clinical phenotype as a result of interaction between genetic susceptibility and environmental risk factors. Hence, the search for susceptibility genes for type 2 diabetes in man is difficult. READ MORE

  5. 3. Islet insulin secretory patterns in diabetes and the role of UCP2

    Author : Jian-Man Lin; Valdemar Grill; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). READ MORE