Search for dissertations about: "NOESY"

Showing result 1 - 5 of 15 swedish dissertations containing the word NOESY.

  2. 1. Diffusion in cationic vesicle and micellar solutions- a NMR study

    Author : Cecilia Groth; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; vesicles; Stopped-flow; micellar kinetics; water transport; DSC; Gemini surfactant; permeability; NOESY; Cationic surfactant; NMR diffusometry; extrusion;

    Abstract : Double tailed cationic surfactants are the active component in softeners. In the beginning of the 90s the active component in softener formulations was changed from a hydrolytically stable dialkyl dimethyl ammonium chloride (dialkyl quat) to a cleavable and biodegradable product containing ester groups in the alkyl chains (dialkyl ester quat). READ MORE

  4. 2. Chloromethane Complexation by Cryptophanes : Host-Guest Chemistry Investigated by NMR and Quantum Chemical Calculations

    Author : Zoltan Takacs; Jozef Kowalewski; Mikael Akke; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Host–guest complexes; inclusion phenomenon; cryptophanes; NMR; kinetics; activation energy; dipolar interaction; exchange; quantum chemical optimization; calculated chemical shifts; NOESY; cavity size; fysikalisk kemi; Physical Chemistry;

    Abstract : Host–guest complexes are widely investigated because of their importance in many industrial applications. The investigation of their physico–chemical properties helps understanding the inclusion phenomenon. The hosts investigated in this work are cryptophane molecules possessing a hydrophobic cavity. READ MORE

  5. 3. Synthesis of Nitrogen Heterocycles via 1,3-Dipolar Cycloadditions - Method Development and Applications

    Author : Johan Johansson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2D NOESY; alkyne; 3-dipolar cycloaddition; azomethine ylide; 1; CNTs; azide; sequential one-pot; SEM EDS; microwave heating; RuAAC; CuAAC;

    Abstract : Because of the diverse properties displayed by nitrogen heterocycles, they are one of the most commonly used structural elements in drug discovery. Due to this variation in properties, however, the chemistry and synthetic pathway to each heterocycle is unique. READ MORE

  6. 4. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Author : Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

    Abstract : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. READ MORE

  7. 5. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Author : Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE