Search for dissertations about: "NOS2"

Showing result 1 - 5 of 6 swedish dissertations containing the word NOS2.

  2. 1. Nucleator-driven assembly of curli organelles and their pathophysiological role in E. coli septic shock

    Author : Zhao Bian; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Assembly; Curli; NOS2; Nucleator; Sepsis;

    Abstract : The understanding of how polymeric surface structures are assembled in bacteria is one of general interests, which can provide insight into details of macromolecule interactions, and study how proteins fold into domains as assembly modules for building organelles. Protein-protein interactions in various subcellular compartments lead to the assembly of fimbriae at bacterial cell surfaces. READ MORE

  4. 2. Molecular genetic aspects of colorectal cancer development

    Author : Karin Fransén; Annika Lindblom; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Colorectal cancer (CRC) is one of the most common cancer diseases in the world after lung and female breast cancer and approximately 945 000 new cases are diagnosed every year. CRC is caused by genetic alterations in the DNA, which results in cell cycle acceleration, escape from apoptosis, senescence, angiogenesis, invasion and metastasis. READ MORE

  5. 3. Effects of BCG-treatment on urinary bladder cancer with focus on nitric oxide

    Author : Tomas Thiel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Intravesical Bacillus Calmette-Guérin is used as a single agent or adjuvant therapy in the treatment of non-muscle invasive bladder cancer. In spite being one of the most efficient immunological treatments in cancer, BCG for bladder cancer is afflicted with a number of unsolved problems. READ MORE

  6. 4. Inflammation-associated genes and genetic variations in colorectal cancer

    Author : Nils Elander; Peter Söderkvist; Karin Fransén; Mef Nilbert; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Colorectal cancer is a major cause of morbidity and mortality around the world, each year affecting about one million individuals worldwide. The disease is characterized by an accumulation of genetic alterations, and a sequence of events leading to the development of an invasive and metastasising tumour. READ MORE

  7. 5. Interaction of genetic susceptibility and traffic-related air pollution in cardiovascular disease

    Author : Anna Levinsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular disease; genetic variants; air pollution; gene-environment interaction;

    Abstract : This thesis aimed at investigating gene-environment interaction in cardiovascular disease (CVD). A study population of 618 coronary heart disease (CHD) cases (of which 192 first-time acute myocardial infarction (AMI) patients) and 3614 randomly selected population controls was genotyped for genetic variants in genes coding for nitric oxide synthase (NOS) and glutathione s-transferase (GST). READ MORE