Search for dissertations about: "Naphthoxylosides"

Found 4 swedish dissertations containing the word Naphthoxylosides.

  2. 1. Naphthoxylosides Investigations into glycosaminoglycan biosynthesis

    Author : Mårten Jacobsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; proteoglycan; Organic chemistry; nucleophilic aromatic substitution; thioether; glycosaminoglycan; xylosides; naphthoxylosides;

    Abstract : Glycosaminoglycans (GAGs) are members of a family of polysaccharide structures consisting mostly of repeating disaccharide units. Most GAGs are attached to specific serine residues in proteins to form proteoglycans (PGs). READ MORE

  4. 2. Synthetic studies on naphthoxylosides - labeled compounds and mechanistic studies on acetals

    Author : Richard Johnsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fluorescent xylosides; Carbohydrates; Naphthoxylosides; Cancer; Mechanistic studies; Radioactive xylosides; Acetals;

    Abstract : Labeled analogs to an antiproliferative naphthoxyloside have been synthesized and evaluated. Our investigations have shown that the fluorescently labeled analogs are poor structural analogs, and the physical and biological properties are altered to a large extent. READ MORE

  5. 3. Tumor Selective Antiproliferative Naphthoxylosides

    Author : Ulrika Aili; Glykobiologigruppen; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosaminoglycan; proteoglycan; heparan sulfate; xyloside; naphthoxyloside; histone H3 acetylation;

    Abstract : Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. READ MORE

  6. 4. Naphthoxylosides – Probing the β4GalT7 active site

    Author : Anna Siegbahn; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Proteoglycans (PGs) is a class of highly anionic macromolecules that consist of one or more linear polysaccharide chains (glycosaminoglycans, GAGs) covalently attached to a core protein. The biological functions of PGs are mainly due to the interactions of GAG chains with various protein ligands and regulatory factors, such as cytokines and growth factors. READ MORE