Search for dissertations about: "Nephroblastoma"

Found 3 swedish dissertations containing the word Nephroblastoma.

  2. 1. Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour

    Author : Daniel Sehic; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms Tumour; Nephroblastoma; SIX1; Blastema; biomarker; Immunochemisty; Immunohistochemestry;

    Abstract : The aim of this thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. READ MORE

  4. 2. Angiogenesis in childhood malignancies

    Author : Erik Sköldenberg; Rolf Christofferson; Göran Läckgren; Agneta Nordenskjöld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Angiogenesis Factor; Biopsy; Needle; Neovascularization; Pathologic; Nephroblastoma; Reference value; Kirurgi; Surgery; Kirurgi; Pediatric Surgery; kirurgi; särskilt barnkirurgi;

    Abstract : Angiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors. READ MORE

  5. 3. Mechanisms and Consequences of Chromosomal Instability in Malignant tumours

    Author : Ylva Stewénius; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; structural rearrangement; Ewing family tumour; Chromosomal instability; nephroblastoma; Wilms tumour; chromosomal aberration; anaphase bridge; subtelomeric FISH; breakage-fusion-bridge cycle;

    Abstract : In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. READ MORE