Search for dissertations about: "Neuro toxicity"

Found 5 swedish dissertations containing the words Neuro toxicity.

  2. 1. Long acting local anaesthetics - a study in rats

    Author : Henrik Dyhre; Anestesiologi och intensivvård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; in vivo and effect kinetics; Comparison of in vitro; Neuro toxicity; Infraorbital nerve block; Sciatic nerve block; Lipid depot formulation;

    Abstract : Local anaesthetics provide excellent pain relief after central and peripheral nerve blocks. However, in many clinical situations there is an insufficient duration of action to allow effective treatment of long-term pain with single injection techniques. This problem became the focus of the present studies. READ MORE

  4. 2. Methylsulphonyl-chlorobenzenes and the olfactory system : Comparative toxicity of the 2,5- and 2,6-dichlorinated isomers in mice

    Author : Fariba Bahrami; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; toxikologi; Toxicology;

    Abstract : Methyl sulphone metabolites of chlorinated aryl hydrocarbons are persistentenvironmental pollutants that can bioaccumulate in animals and humans. Little is known about the toxicological effects of these metabolites and this thesis is an attempt to increase this limited knowledge. READ MORE

  5. 3. Age dependent beta-amyloid isoforms and implications of different drug treatments as studied in different transgenic mouse models and cell lines

    Author : Tamanna Mustafiz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Amyloid-β (Aβ) peptide is the main component of the the amyloid plaques in Alzheimer’s Disease (AD) and has been implicated to be the cause of the disease. During the last decade it has become increasingly evident that soluble, oligomeric forms of Aβ are more toxic to neurons than the plaques and might play an important role in the disease pathogenesis. READ MORE

  6. 4. Studies on Islet Amyloid Polypeptide Aggregation : From Model Organism to Molecular Mechanisms

    Author : Sebastian Schultz; Gunilla Torstensdotter Westermark; Anne Simonsen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The proper folding of a protein into its defined three--?dimensional structure is one of the many fundamental challenges a cell encounters. A number of tightly controlled pathways have evolved to assist in the proper folding of a protein, but also to aid in the removal of misfolded proteins. READ MORE

  7. 5. Targeting ALK and WIP1 : neuroblastoma precision medicine under development

    Author : Diana Treis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuroblastoma is the childhood solid tumor accountable for the largest number of deaths, calling for improved treatment. Some genetic alterations are considered crucial in driving initiation and progression of neuroblastoma. These are usually associated with poor prognosis and are viewed as potential therapeutic targets. READ MORE