Advanced search

Showing result 1 - 5 of 21 swedish dissertations matching the above criteria.

2. 1. Biomarkers in non-small cell lung carcinoma : methodological aspects and influence of gender, histology and smoking habits on estrogen receptor and epidermal growth factor family receptor signalling

   Author : Christina Karlsson; Karin Piehl-Aulin; Ulf Tidefelt; Gisela Helenius; Leif Johansson; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-small cell lung carcinoma; estrogen receptor; epidermal growth factor receptor; HER-4; tissue microarray; immunohistochemistry; smoking habits; in situ hybridisation; Onkologi; Oncology;

   Abstract : Non-small cell lung carcinoma is a leading cause of cancer mortality worldwide. There are gender and smoking associated differences both in tumour types and clinical outcome. Squamous cell carcinomas (SCC) are more frequent among smoking men while females develop adenocarcinomas (ADCA). READ MORE

4. 2. Mutation and immune profiling of non-small cell lung cancer

   Author : Linnéa La Fleur; Johan Botling; Fernando López-Ríos; Uppsala universitet; []
   Keywords : Non-small cell lung cancer; Tumor microenvironment; Tumor-associated macrophages; Immune infiltrates; PD-L1; Mutation patterns; Immune therapy; MARCO; TP53; STK11; KRAS;

   Abstract : Several novel therapies that target molecular alterations and immune checkpoints in lung cancer have been introduced in the last decade. Still, only a minority of patients obtain long term disease control and overall survival remains poor. READ MORE

5. 3. Molecular Characterisation and Prognostic Biomarker Discovery in Human Non-Small Cell Lung Cancer

   Author : Karolina Edlund; Patrick Micke; Martin Schuler; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-small cell lung cancer; biomarker; prognosis; microarray; copy number aberration; Medical Science; Medicinsk vetenskap;

   Abstract : Non-small cell lung cancer (NSCLC) constitutes a clinically, histologically, and genetically heterogeneous disease entity that represents a major cause of cancer-related death. Early-stage patients, who undergo surgery with curative intent, experience high recurrence rates and the effect of adjuvant treatment is modest. READ MORE

6. 4. Heterogeneity of human metabolism in health and disease: a modelling perspective

   Author : Pouyan Ghaffari Nouran; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer metabolism; fatty acid metabolism; genome-scale metabolic models; community modeling; heterogeneity; lung cancer; amino acids metabolism; gut microbiome;

   Abstract : Metabolism is broadly defined as the sum of biochemical reactions within cells that are involved in maintaining the living state of the organism. Profound importance of metabolism comes from the fact that it is the sole source of energy that allows life to resist to be degraded into entropy. READ MORE

7. 5. Molecular aspects of cellular radiosensitivity in small cell lung carcinoma

   Author : Florin Sirzén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : lung carcinoma; radiosensitivity; DNA double-strand breaks; DNA-dependent protein kinase; cell cycle checkpoints; apoptosis;

   Abstract : To clarify some important molecular aspects of radiosensitivity (RS) in small cell (SCLC) compared with non small cell (NSCLC) lung carcinoma, five studies focusing on DNA damage repair, cell cycle checkpoints and apoptosis were performed. As repair of DNA double-strand breaks (DNA dsb), a critical DNA lesion, may be an important determinant of cellular RS, induction and rejoining of DNA dsb were studied using pulsed field gel electrophoresis in a radiosensitive SCLC line, U-1285 and a radioresistant NSCLC line, U-1810 (paper I). READ MORE