Search for dissertations about: "Norovirus VA387"

Found 5 swedish dissertations containing the words Norovirus VA387.

  2. 1. Computational Prediction and Analysis of Protein-Carbohydrate and Protein-Protein Interactions

    Author : Ashok Krishna Chaitanya Koppisetty; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arylsulfatase-A; Norovirus VA387; Molecular Dynamics; Saposin B; Computational Docking;

    Abstract : The structure and energetics of protein-carbohydrate and protein-protein interactions are of great interest due to their importance in many biological phenomena. Two cases of protein-carbohydrate interactions and one case of protein-protein interactions were predicted and analyzed using existing computational methods. READ MORE

  4. 2. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics

    Author : Francesco Strino; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histo-blood group antigens; Burkholderia cepacia; genetic algorithms; norovirus; selenoglycosides; sugar conformations; thioglycosides; saccharide conformations;

    Abstract : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. READ MORE

  5. 3. Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands

    Author : Waqas Nasir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Norovirus-glycan interactions;

    Abstract : Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world get infected with NVs annually, of which 200,000 cases are estimated to be fatal. READ MORE

  6. 4. Application and Development of Computational Methods for Structure-based Drug Discovery

    Author : Ashok Krishna Chaitanya Koppisetty; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Researchers involved in drug discovery need tools to support their decisions regarding which of many available chemical entities could be developed into potent drug candidates. The qualitative and quantitative results from computational docking methods constitute the basis for structure-based rational design of inhibitors in the early stages of drug discovery. READ MORE

  7. 5. Computer-Assisted Carbohydrate Structural Studies and Drug Discovery

    Author : Magnus Lundborg; Göran Widmalm; Hans-Christian Siebert; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; molecular docking; molecular dynamics simulation; fragment-based virtual screening; NMR spectroscopy; computer-aided drug design; computer-aided structure elucidation; glycosyltransferases; Escherichia coli; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : Carbohydrates are abundant in nature and have functions ranging from energy storage to acting as structural components. Analysis of carbohydrate structures is important and can be used for, for instance, clinical diagnosis of diseases as well as in bacterial studies. The complexity of glycans makes it difficult to determine their structures. READ MORE