Search for dissertations about: "OGTT"

Showing result 1 - 5 of 41 swedish dissertations containing the word OGTT.

  2. 1. Metabolomics of Weight Loss and Weight Maintenance in Obese Humans

    Author : Nina Geidenstam; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; Obesity; Weight Loss; Weight Maintenance; OGTT; Metabolites; Insulin Resistance; Amino Acids;

    Abstract : .... READ MORE

  4. 2. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

    Author : Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. READ MORE

  5. 3. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

    Author : Cecilia Nagorny; Diabetes - molekylär metabolism; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

    Abstract : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. READ MORE

  6. 4. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

    Author : Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

    Abstract : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. READ MORE

  7. 5. Microdialysis as a tool for the management of diabetes mellitus

    Author : Neda Rajamand Ekberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Microdialysis; microdialysis flow rate; adipose tissue; glucose; lactate; pyruvate; glycerol; insulin; IGFBP- 1; OGTT;

    Abstract : Diabetes complications are the result of impaired metabolic control. A continuous glucose monitoring system could be a tool to improve metabolic control. Microdialysis is a minimal invasive method for investigating tissue metabolism in-vivo and provides a novel opportunity for glucose monitoring in patients with diabetes (DM). READ MORE