Search for dissertations about: "Oommen P. Varghese"

Found 3 swedish dissertations containing the words Oommen P. Varghese.

  2. 1. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

    Author : Oommen P. Varghese; Lars Engman; Jacek Stawinski; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chemically modified oligonucleotides; azetidine; aza-ENA-T; cyanomethylene locked; free energy of activation; diaxial interactions; chair conformation; stable duplex; human serum; snake venom phosphodiesterase; antisense agents; RNase H; Organisk kemi; Chemistry; Kemi;

    Abstract : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. READ MORE

  4. 2. Insights into Covalent Chemistry for the Developmen­t of Biomaterials

    Author : Daniel Bermejo-Velasco; Oommen P. Varghese; Jöns Hilborn; Frey Holger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronic acid; hydrogel; biomaterials; covalent chemistry; biomedical applications; MRI; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Abstract : Covalent cross-linking chemistry is currently exploited in the preparation of biomaterial for biomedical applications. Choice of these chemistries for the preparation of biomaterials and bioconjugates strongly influences the biological output of these materials. READ MORE

  5. 3. Regulating Gene Expression to Promote Osteoblastic Differentiation of Stem Cells

    Author : Maruthibabu Paidikondala; Oommen P. Varghese; Jöns Hilborn; Laura Creemers; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Abstract : Bone is a tissue that heals by itself, unless the defect is too large (critical size). Today, novel regenerative medicine approaches have emerged as an alternative to treat such defects. This thesis explores alternative therapeutic strategies for bone tissue engineering which are biocompatible and clinically translatable. READ MORE