Search for dissertations about: "Oral Delivery"

Showing result 1 - 5 of 68 swedish dissertations containing the words Oral Delivery.

2. 1. Oral delivery of macromolecules formulated with permeation enhancers

   Author : Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

   Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE

4. 2. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

   Author : Eva Krondahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE

5. 3. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

   Author : Cecilia Wadell; Frans Merkus; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE

6. 4. Swedish School-leaving Students' Oral Proficiency in English : Grading of Production and Analysis of Performance

   Author : Stellan Sundh; Merja Kytö; Torsten Lindblad; Sauli Takala; Uppsala universitet; []
   Keywords : HUMANIORA; HUMANITIES; Linguistics; second language learning; oral testing; rating criteria; oral proficiency; grading spoken English; student production; validity; reliability; 19-year-old Swedish learners; Lingvistik; Linguistics; Lingvistik; English; Engelska;

   Abstract : This study deals with the testing and grading of Swedish school leaving students’ oral proficiency in English, and with certain aspects of these students’ linguistic competence. The analyses and results are based on material drawn from an assessment project carried out at Gothenburg University in 1993. READ MORE

7. 5. Ceramic Materials as Drug Delivery Systems

   Author : Amina Vazda; Håkan Engqvist; Santos Hélder; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery; ceramics; Abuse deterrent; inhalation; single-crystals;

   Abstract : The aim of this thesis is to evaluate ceramic materials for drug delivery drugs applications. Three delivery routes were investigated; abuse-deterrent oral formulation, inhalation, and novel ceramic crystals with drug entrapped. A geopolymer matrix was developed in order to withstand non-medical abuse such as crushing, snorting, extraction etc. READ MORE