Search for dissertations about: "Oral formulation"
Showing result 1 - 5 of 33 swedish dissertations containing the words Oral formulation.
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1. Ceramic Materials for Administration of Potent Drugs
Abstract : This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions.Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. READ MORE
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2. Oral delivery of macromolecules formulated with permeation enhancers
Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE
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3. Predicting oral performance of lipid-based formulations using in vitro methods
Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE
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4. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs
Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE
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5. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System
Abstract : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. READ MORE