Search for dissertations about: "Organ of Corti"

Showing result 1 - 5 of 11 swedish dissertations containing the words Organ of Corti.

  2. 1. Applications of organ culture of the mouse inner ear

    Author : Diana Berggren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ culture; embryonic inner ear; intercellular junctions; aminoglycosides; statoacoustic ganglion; intermediate filaments; collagen; endolymph;

    Abstract : The embryonic mouse inner ear was used as a model with which to study ototoxicity and tissue interactions. The inner ear anlage can be explanted and cultured in vitro from about the 12th gestational day (gd), and will differentiate parallel with the inner ear developing in vivo until a time corresponding to birth (21st gd). READ MORE

  4. 2. Imaging the organ of Corti in vitro and in vivo

    Author : Igor Tomo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Recent developments in imaging techniques, namely confocal laser scanning microscopy, offer new tools in exploration of the structure and function of the inner ear. The optical sectioning property of the confocal microscope enables investigation of living cells deeper within a labeled intact tissue. READ MORE

  5. 3. Hair cell and organ of corti responses to normal and intense acoustic stimulation

    Author : Anders Fridberger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; outer hair cells; calcium; pressure changes; micromechanics; noise-induced hearing loss; fluorescent indicators; laser interferometry; temporal bone preparation; guinea pig;

    Abstract : The principal aims of the studies described in this thesis were to develop an in vitro model for studying acoustic overstimulation at the cellular level, to define the electrical and mechanical response characteristics of the perfused temporal bone preparation, and to investigate the effects of intense sound stimulation on the calcium levels of the hair cells in the intact hearing organ. In the in vitro model for acoustic overstimulation, isolated cochlear outer hair cells were subjected to a pressure jet emanating from a glass micropipette aimed at the cell body. READ MORE

  6. 4. Pharmacokinetics and inner ear transport of cisplatin

    Author : Victoria Hellberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible hearing loss. READ MORE

  7. 5. Physiological aspects of cochlear excitation and neurotransmitter release

    Author : Wanje Jäger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; cochlear microphonics; summating potential; vibratory response; tetracaine; aspartate; glutarnate; neurotransmitter; noise; hearing loss;

    Abstract : Using an in vitro model of the guinea pig, the temporal bone preparation, cochlear physiology was studied. By perfusion of the scala tympani with oxygenated culture medium, the responses of the hearing organ to sound stimuli were maintained over several hours and the functional state was followed by monitoring the electrophysiological parameters cochlear microphonics (CM) and summating potential (SP). READ MORE