Search for dissertations about: "Origami"
Showing result 1 - 5 of 19 swedish dissertations containing the word Origami.
-
1. Protein Folding and DNA Origami
Abstract : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. READ MORE
-
2. Nonlinear Programming - Robust Models and Applications
Abstract : The major theme of this thesis is nonlinear programming with an emphasis on applications and robust models. The thesis has two parts. The first three papers comprise the first part. Here, we discuss robustness properties of optimal solutions to a variety of models. READ MORE
-
3. Applications of DNA origami encoded nanoscale patterns
Abstract : It was almost four decades ago when the recognition of DNA’s potential use as a programmable, self-assembling building material for nanostructures led to the birth and rapid expansion of the field of DNA nanotechnology, but it was two decades later when the development of the DNA origami technique initiated the widespread use of DNA based nanoconstructs through the simplification of the design process and the reduction of the required control over the quality and stoichiometry of the assembly components by using a single-stranded “scaffold” DNA and a set of “staple” oligonucleotides that “fold” the mentioned scaffold DNA into a predesigned shape by binding different regions of the scaffold strand together. This robust approach not only permitted the construction of intricate two- and three-dimensional structures, but it also allowed the design and fabrication of molecular patterns with unprecedented accuracy as each functionalizible component’s relative position in the DNA origami structure is known to nanometer precision. READ MORE
-
4. Custom-tailored DNA origami mechanics for cellular applications
Abstract : DNA molecules have been used as the building block for the self-assembly of artificial nanostructures. In particular, the DNA origami method has made the design of DNA nanostructures more robust and approachable. READ MORE
-
5. Development of DNA origami-based tools for cancer treatment
Abstract : DNA has been used as material for the assembly of objects at different scales. Particularly, the introduction of DNA origami has been inspiring the design and construction of many different versions of DNA nanostructures for, especially, biomedical applications. READ MORE
