Search for dissertations about: "Oskar Karlsson"

Showing result 1 - 5 of 8 swedish dissertations containing the words Oskar Karlsson.

  2. 1. Metagenomic characterisation of the gastrointestinal virome of neonatal pigs

    Author : Oskar Karlsson Lindsjö; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Microorganisms that colonise the gastrointestinal tract are responsible for a large portion of the genetic diversity of the body. These microorganisms are of bacterial, archaeal and viral origin. The living space of these microorganisms, the microbiome, holds numerous interactions both between each other and the host. READ MORE

  4. 2. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) : Brain changes and behavioral impairments following developmental exposure

    Author : Oskar Karlsson; Eva Brittebo; Nils Gunnar Lindquist; Erika Roman; Sandra Ceccatelli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Abstract : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. READ MORE

  5. 3. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

    Author : Oskar Alskär; Maria C Kjellsson; Mats O Karlsson; Jenny Y. Chien; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. READ MORE

  6. 4. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

    Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

  7. 5. Toxicological studies of di-n-butyl phthalate (DBP) : Impact on the reproductive system and gut microbiota

    Author : Radwa Almamoun; Oskar Karlsson; Paula Pierozan; Harri Alenius; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dibutyl phthalate; Antiandrogen; Gut microbiota; Reproductive toxicity; Endocrine disrupting chemicals; Environmental contaminants; Phthalates; Plastics; 3D cell culture model; Exposome; Toxicology; Environmental Sciences; miljövetenskap;

    Abstract : The potential health impact of exposure to anthropogenic chemicals has raised major concerns worldwide. Phthalates are mainly used in the plastic industry and have been associated with adverse effects in humans. Di-n-butyl phthalate (DBP) is one of the dominant phthalates with a ubiquitous presence in the environment. READ MORE