Search for dissertations about: "P-gp"

Showing result 1 - 5 of 23 swedish dissertations containing the word P-gp.

2. 1. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa

   Author : Mari Thörn; Lars Lööf; Anders Rane; Ellen Vinge; Uppsala universitet; []
   Keywords : Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

   Abstract : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). READ MORE

4. 2. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

   Author : Pär Matsson; Per Artursson; Ulf Norinder; Peter Swaan; Uppsala universitet; []
   Keywords : Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

   Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE

5. 3. Molecular heterogeneity of prostate cancer bone metastasis

   Author : Erik Bovinder Ylitalo; Pernilla Wikström; Anders Bergh; Maria Brattsand; Vessela Kristensen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; CRPC; castration-resistant; androgen receptor; splice variant; abiraterone; cabazitaxel; ABCB1; cholesterol; Mdr1; P-gp; bone metastasis; immune response; metabolism; osteoblast; osteoclast; BMP; methylation;

   Abstract : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. READ MORE

6. 4. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo

   Author : Eva Persson; Hans Lennernäs; Bertil Abrahamsson; Peter Langguth; Uppsala universitet; []
   Keywords : Biopharmacy; solubility; drug dissolution; food effects; poorly soluble drugs; P-gp inhibition; drug absorption; pemeability; bile acids; phospholipids; human intestinal fluid; simulated intestinal fluid; neutral lipids; solid phase extraction; HPLC; Efflux; Biofarmaci;

   Abstract : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. READ MORE

7. 5. Pharmacological properties of radiotracers that measure p-glycoprotein function and density

   Author : Pavitra Kannan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Energy-dependent transporters of the ATP-binding cassette (ABC) family regulate the movement of molecules across cellular membranes. Several of these transporters are expressed in the endothelial cells of brain microvessels (blood-brain barrier) to protect brain tissue from exposure to toxins in the blood. READ MORE