Search for dissertations about: "PAI-1 cancer"
Showing result 1 - 5 of 12 swedish dissertations containing the words PAI-1 cancer.
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1. Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy
Abstract : BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. READ MORE
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2. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression
Abstract : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. READ MORE
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3. The climacteric. Management and attitudes among women and physicians
Abstract : Aims: Paper I: To longitudinally assess the prevalence of climacteric symptoms, the use of hormone replacement therapy (HRT) and life-style factors in the same women in 1992 (aged 46-62 years) and in 1998 (aged 52-68 years). Paper II: To study changes in (i) the prevalence of HRT use and (ii) attitudes and knowledge about the climacteric among 46-62 years old women resident in Göteborg 1992 and 1998. READ MORE
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4. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition
Abstract : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. READ MORE
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5. The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and Linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2
Abstract : The progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. READ MORE