Search for dissertations about: "PAMAM"

Found 4 swedish dissertations containing the word PAMAM.

  2. 1. Nanostructured surfaces created by the interactions of dendrimers and oppositely charged amphiphiles

    Author : Marianna Yanez; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PAMAM; Surfactant; SDS; Lipid; Bilayer; Model Biomembrane; Nucleolipid; DLPA; DLPU; DNA; RNA; Neutron Reflectometry; Poly amidoamine ; Interface; Adsorption; Polyelectrolyte;

    Abstract : The research described in this thesis aims to understand the interactions between cationic poly(amidoamine) (PAMAM) dendrimers and small oppositely charged amphiphiles at the solid-liquid and air-liquid interfaces in relation to the bulk solution behavior. There is high interest in PAMAM dendrimers because they are well-defined polymers with a hierarchical architecture which makes them promising materials as nanocapsules and gene vectors. READ MORE

  4. 2. Controlling DNA compaction and the interaction with model biomembranes

    Author : Marie-Louise Ainalem; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; model biomembrane; DNA compaction; cryo-TEM; null ellipsometry; dynamic light scattering; toroid; bilayer; neutron reflectivity; dendrimer; PAMAM; DNA; poly amido amine ;

    Abstract : The studies described in this thesis forms part of a larger collaborative project, Neonuclei, with the objective to design a module for packaging the negatively charged DNA into a ”neonucleus” with transcription competence. There are many applications that require control of DNA compaction, i.e. packaging or condensation. READ MORE

  5. 3. Dendrimer-mediated gene delivery: Effect of polymer structure on cellular response

    Author : Kristina Fant; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene therapy; DNA condensation; cationic polymers; toxicity; non-viral vector; drug delivery; polyplex; PAMAM dendrimers;

    Abstract : The delivery of nucleic acids to cells, in vitro and in vivo, is becoming a realistic approach for intervention with gene expression at a molecular level. It can be used to repair malfunctioning genes or to introduce new functionalities, with the most important application being clinical treatment of human diseases. READ MORE

  6. 4. Engineered nanomaterials for biomedical applications

    Author : Neus Feliu Torres; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Engineered nanomaterials (ENM) have emerged as attractive and promising candidates for a wide range of advanced applications including in particular in medicine. However, the increased development of ENM raises the need to carefully assess their potential impact on human health and environment. READ MORE