Search for dissertations about: "PARP1"

Showing result 1 - 5 of 12 swedish dissertations containing the word PARP1.

  2. 1. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

    Author : Siker Kimbung; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

    Abstract : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. READ MORE

  4. 2. Molecular mechanisms underlying the activation of ALC1 nucleosome remodeling

    Author : Luka Bacic; Sebastian Deindl; Stefan D. Knight; Lari Lehtiö; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; nucleosome; ADP-ribosylation; chromatin; remodeling; PARP1; HPF1; DNA damage; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Packaging DNA into chromatin represses essential DNA-based processes, such as transcription, DNA replication, and repair. To change the accessibility of DNA, cells have evolved a set of enzymes referred to as chromatin remodelers that act on the basic repeat unit of chromatin,  the nucleosome. READ MORE

  5. 3. Gene regulation by different proteins of TGFβ superfamily

    Author : Varun Maturi; Aristidis Moustakas; Anita Göndör; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

    Abstract : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. READ MORE

  6. 4. A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1) in cancer

    Author : Dandan Song; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Activator protein-1 (AP-1) is a transcriptional factor complex that mainly consists of Fos and Jun family members. Jun proteins can form both homodimers and heterodimers, whereas Fos family members only form heterodimers with the Jun family. Fra-1 is a member of the Fos family proteins and plays a vital role in breast cancer progression. READ MORE

  7. 5. Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression

    Author : Anna Lewandowska Ronnegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome Conformation Capture assay (4C) and Chromatin in situ Proximity (ChrISP) techniques, we show that transcriptionally active circadian genes meet in space with repressed lamina-associated domains (LADs), and that these interactions are under the control of the circadian clock. READ MORE