Search for dissertations about: "PAX6."

Showing result 1 - 5 of 19 swedish dissertations containing the word PAX6..

  2. 1. Genetic analysis of genes found on the 4th chromosome of Drosophila - emphasizing the developmental context of Pax6

    Author : Jesper Kronhamn; Åsa Rasmuson-Lestander; Kevin Moses; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Pax6; twin of eyeless; headless flies; head development; eye development; eyeless; Minute; RpS3A; regulatory region; Drosophila; Genetik; Genetics; Genetik; Genetics; genetik;

    Abstract : The small size and the lack of recombination set the fourth chromosome of Drosophila melanogaster apart from the other chromosomes. I have shown that the Minute gene on chromosome 4, earlier named Minute-4, encodes the ribosomal protein RpS3A. Two Pax6 genes, eyeless (ey) and twin of eyeless (toy) are also located on chromosome 4. READ MORE

  4. 2. Human neural stem cells: region-specific properties and prospects for cell therapy

    Author : Therese Kallur; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pax6; fetal cortex and striatum; human; neural stem cells; transplantation; neurospheres; stroke; overexpression; region-specific properties;

    Abstract : Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. READ MORE

  5. 3. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Author : André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Abstract : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. READ MORE

  6. 4. Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation

    Author : Håkan Toresson; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pbx; meis; sonic hedgehog; small eye; pax6; gsh2; gsh1; cerebral cortex; striatum; telencephalon; mutant; development; mouse; embryo; retinoic acid; Clinical biology; Klinisk biologi;

    Abstract : The striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. READ MORE

  7. 5. On Aniridia in Sweden and Norway

    Author : Ulla Edén; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gillespie syndrome; Aniridia; PAX6 gene;

    Abstract : Introduction Aniridia (iris more or less missing), is a congenital, dominant, inherited, serious and sight-threatening disease, most often appearing as an isolated eye disorder. It is caused by mutations in the PAX6 gene, the master gene of the development of the eye. Typically, Aniridia causes severe visual impairment. READ MORE