Search for dissertations about: "PCR-SSP"

Showing result 1 - 5 of 7 swedish dissertations containing the word PCR-SSP.

  2. 1. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

    Author : Ewa Lavant; Malmö högskola; []
    Keywords : HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Abstract : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. READ MORE

  4. 2. Human leukocyte antigens with special reference to association and linkage in multiple sclerosis

    Author : Anna Fogdell-Hahn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HLA; MHC; multiple sclerosis; narcolepsy; lod score; linkage.;

    Abstract : The polymorphism of HLA (human leukocyte antigen) is extensive. Allelic variation has previously been detected by cellular and serological methods. Today a variety of genomic typing techniques have been developed, which give higher resolution and a possibility to detect single nucleotide variations. READ MORE

  5. 3. HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation

    Author : Anna Aldener-Cannavá; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The HLA (Human Leukocyte Antigen) region is the most polymorphic in the human genome. The extended polymorphism contributes to the ability both of individuals and populations to combat diversity in the pathogens to which they are exposed. READ MORE

  6. 4. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

    Author : Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

    Abstract : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. READ MORE

  7. 5. Immunogenetic studies of multiple sclerosis

    Author : Arturs Ligers; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; CTLA-4; HLA-A2; HLA-A3; HLA-DRB1*15; HLA-DRB1*;

    Abstract : Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Several genetic factors are likely to be of importance for MS rather than one factor. READ MORE