Search for dissertations about: "PD1"

Showing result 1 - 5 of 16 swedish dissertations containing the word PD1.

  2. 1. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach

    Author : Veronica Magnusson; Jerry Lanchbury; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). READ MORE

  4. 2. Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders

    Author : Priya Sakthivel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). READ MORE

  5. 3. Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells

    Author : Maria Karvouni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival rates, patients still experience relapse and cure remains elusive. READ MORE

  6. 4. Strategies to optimize natural killer cell functions in the tumor microenvironment

    Author : Katharina Helene Susek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer (NK) cell-based therapies are employed in early phase clinical trials. READ MORE

  7. 5. Studies of the two redox active tyrosines in Photosystem II

    Author : Nigar Ahmadova; Fikret Mamedov; Stenbjörn Styring; Robert Burnap; Uppsala universitet; []
    Keywords : Photosystem II; Tyrosine Z and D; proton-coupled electron transfer;

    Abstract : Photosystem II is a unique enzyme which catalyzes light induced water oxidation. This process is driven by highly oxidizing ensemble of four Chl molecules, PD1, PD2, ChlD1 and ChlD2 called, P680. Excitation of one of the Chls in P680 leads to the primary charge separation, P680+Pheo-. READ MORE