Search for dissertations about: "PET ligand"

Showing result 1 - 5 of 27 swedish dissertations containing the words PET ligand.

  2. 1. Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors

    Author : Fredrik Jeppsson; Anna-Lena Ström; Kerstin Iverfeldt; Samuel Svensson; Martin Hallbeck; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s disease; Diagnostics; Treatment; PET ligand; BACE1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a very complex disorder and the most common form of dementia. The two pathological hallmarks of AD are extracellular amyloid-β (Aβ) plaques in cerebral cortex, and intraneuronal neurofibrillary tangles. READ MORE

  4. 2. Characterization of [18F]flutemetamol binding properties : A β-amyloid PET imaging ligand

    Author : Kerstin Heurling; Mark Lubberink; Jens Sörensen; Julie Price; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; molecular imaging; amyloid; tracer validation; Radiology; Radiologi;

    Abstract : The criteria for diagnosing Alzheimer’s disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. READ MORE

  5. 3. Synthesis and application of β-configured [18/19F]FDGs : Novel prosthetic CuAAC click chemistry fluoroglycosylation tools for amyloid PET imaging and cancer theranostics

    Author : Mathias Elgland; Peter Konradsson; Peter Nilsson; Per Hammarström; Olof Solin; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FDG; clickable; PET; synthesis; in vivo imaging; theranostics;

    Abstract : Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. READ MORE

  6. 4. Development of nicotinic receptor ligands for positron emission tomography - from in vitro to in vivo : Binding studies of neuronal nicotinic acetylcholine receptors using different ³H-, ¹1C- and `6Br - labeled ligands

    Author : Wiebke Sihver; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; nicotinic acetylcholine receptor; PET-ligand; in vitro; in vivo; Alzheimer s disease; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in central processes, such as cognitive functionand memory, and play a critical role in neuropathological changes in Alzheimer's disease (AD). The in vivocharacterization of nAChRs by positron emission tomography (PET) may increase our understanding of thefunctional implications of these receptors in AD and their early changes during this disease. READ MORE

  7. 5. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling

    Author : Denise N. Meyer; Kálmán J. Szabó; Dominique Cahard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; boron; allenylboronic acid; BINOL; homopropargyl alcohol; organocatalyst; organoboron; organofluorine; fluorine; fluorine-18; late-stage; labelling; labeling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; radiotracer; hypervalent iodine; benziodoxole; benzoxazepines; diaryliodonium salt; metal-free; neutrophil elastase; NE; neutrophil elastase inhibitor; trifluoromethylation; trifluoromethylthiolation; difluoro enol silyl ethers; organisk kemi; Organic Chemistry;

    Abstract : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. READ MORE