Search for dissertations about: "PLASMODIUM FALCIPARUM cytoadherence thesis"

Showing result 1 - 5 of 11 swedish dissertations containing the words PLASMODIUM FALCIPARUM cytoadherence thesis.

  2. 1. Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria

    Author : Andreas Heddini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; malaria; endothelial adhesion; erythrocyte rosetting; PECAM- 1 CID3 1; immunoglobulins; cerebral malaria; PfEMP- 1; var-genes;

    Abstract : Excessive sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) and uninfected erythrocytes directly blocks the microcirculation and precipitates severe symptoms from the affected organ and is thereby thought to be responsible for the severe complications which may occur during P. falciparum infection. READ MORE

  4. 2. Host cell adhesion of Plasmodium falciparum-infected erythrocytes

    Author : Carl Johan Treutiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; erythrocyte rosetting; cytoadherence; cerebral malaria; PfEMPI; serum proteins; PECAM-I CD31;

    Abstract : Excessive binding of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium (cytoadherence) and to uninfected eryrthrocytes (rosetting) are regarded as key-events in the development of a severe malaria infection. P. falciparum rosetting was confirmed to be associated with the development of cerebral malaria in The Gambia. READ MORE

  5. 3. Heparan sulfate dependent sequestration during Plasmodium falciparum malaria

    Author : Anna Vogt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; heparan sulfate; heparin; animal model.;

    Abstract : Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes obstruction of the deep microvasculature by P. READ MORE

  6. 4. Surface antigens and virulence in Plasmodium falciparum malaria

    Author : Johan Normark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Plasmodium falciparum is an intracellular protozoan that may cause severe forms of malaria. It is a major world health hazard and reaps the highest toll among the children and pregnant mothers of the developing world. An Anopheles mosquito vector injects the pathogen when taking a blood meal. READ MORE

  7. 5. Studies on Plasmodium falciparum asexual blood stage antigens : RAP-2/RSP-2 and Pf332 in focus

    Author : Nancy Awah; Klavs Berzins; Marcel Hommel; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunity; malaria; RBCs; anaemia; Immunology; Immunologi; immunologi; Immunology;

    Abstract : The life cycle of the malaria parasite is very complex and provides a number of potential targets for vaccination. In this thesis, data on two plasmodial asexual blood stage antigens (RAP-2 and Pf332) are presented. READ MORE