Search for dissertations about: "PLC dissertation"
Found 3 swedish dissertations containing the words PLC dissertation.
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1. Bioactive Lipids in Nociception
Abstract : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. READ MORE
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2. Aspects of platelet transfusions and the association between routine coagulation tests and outcome
Abstract : Patients with chemotherapy-induced bone marrow aplasia often develop severe thrombocytopenia which requires platelet transfusion. However, up to 25% of the patients show a less than adequate response to the transfusion. READ MORE
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3. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
Abstract : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. READ MORE