Search for dissertations about: "PMNs"

Showing result 1 - 5 of 24 swedish dissertations containing the word PMNs.

  2. 1. Persistent infection by Yersinia pseudotuberculosis

    Author : Kemal Avican; Maria Fällman; Wyndham W. Lathem; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Persistent infection; RNA-seq; PMNs; Yersinia; Transcriptome; wrba; fnr; rovA; arcA; rfaH; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; immunologi; Immunology;

    Abstract : Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyer’s patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. READ MORE

  4. 2. Apoptotic neutrophils enhance the immune response against Mycobacterium tuberculosis

    Author : Alexander Persson; Olle Stendahl; Per-Arne Oldenborg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

    Abstract : Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, a disease that for years was considered to belong of the past, but tuberculosis is back causing over 2 million deaths per year. The infection can be dormant for decades and an active immune response can prevent the infection from progressing into active disease. READ MORE

  5. 3. Human polymorphonuclear granulocytes in inflammation : studies with an emphasis on nitric oxide

    Author : Gerd Lärfars; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Polymorphonuclear granulocytes; inflammation; nitric oxide; leukotrienes; tumor necrois factor; rheumatoid arthritis; interferon-gamma; chronic granulomatous disease;

    Abstract : The function of the polymorphonuclear neutrophil granulocyte (PMN) is of vital importance in inflammation. For the defense against infections PMNs are armored with different weapons such as chemotaxis, phagocytosis and production of cytotoxic substances. READ MORE

  6. 4. Mechanisms of inflammatory lung injury : Studies in isolated perfused rat lungs

    Author : Anders Ljungman; Östergötlands Läns Landsting; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Isolated perfused rat lungs (IPRLs) were used to study mechanisms andmediators of lung injury due to (i) ischemia-reperfusion (IR) and (ii) endotoxin. To investigate the role of polymorphonuclear neutrophils (PMNs) in IR injury, PMNs were added to the perfusate of IPRLs subjected to IR. READ MORE

  7. 5. Yersinia-phagocyte interactions during early infection

    Author : Linda Westermark; Maria Fällman; Joan Mecsas; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia; dendritic cell; macrophage; neutrophil; T3SS; Infectious Diseases; infektionssjukdomar;

    Abstract : Pathogenic Gram-negative Yersinia species preferentially target and inactivate phagocytic cells of the innate immune defense by translocation of effector Yersinia outer proteins (Yops) into the cells via a type III secretion system. This indicates that inactivation and avoidance of the early innate immune response is an efficient way for Yersinia species to avoid elimination and to cause diseases ranging from mild gastroenteritis (Y. READ MORE