Search for dissertations about: "PPARalpha"

Showing result 1 - 5 of 10 swedish dissertations containing the word PPARalpha.

  2. 1. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Author : Anna Ljungberg; Göteborgs universitet; []
    Keywords : growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Abstract : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. READ MORE

  4. 2. Growth hormone and PPARalpha in the regulation of genes involved in hepatic lipid metabolism

    Author : Caroline Améen; Göteborgs universitet; []
    Keywords : Growth hormone; insulin; SREBP-1; lipogenic enzymes; microsomal triglyceride transfer protein; PPARalpha; LXRalpha; triglycerides; liver;

    Abstract : Growth hormone (GH) plays a key role in the regulation of lipid and lipoprotein metabolism. Its sexually dimorphic secretory pattern regulates many sex-differentiated functions in the liver, such as triglyceride synthesis and VLDL secretion. READ MORE

  5. 3. PPARs in the regulation of gene expression and lipid metabolism in the liver

    Author : Ulrika Edvardsson; Göteborgs universitet; []
    Keywords : PPARalpha; PPARgamma; PPARgamma2; Wy14; 643; rosiglitazone; liver; hepatocytes; insulin; fatty acids; MTP; ADRP; lipid metabolism; apoB; triglycerides.;

    Abstract : Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, regulating genes involved in carbohydrate, lipid and lipoprotein metabolism. Synthetic PPARalpha agonists used in clinic are the fibrates, and their hypotriglyceridemic effect is believed to be the result of decreased VLDL triglyceride secretion and increased turnover of triglyceride-rich lipoprotein particles in the circulation. READ MORE

  6. 4. Characterization of peroxisome proliferator-activated receptor alpha (PPARa) regulated acyl-CoA thioesterases involved in lipid metabolism

    Author : Mary C Hunt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; coenzyme A; bile acid metabolism; lipid metabolism.;

    Abstract : The peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor in the control of lipid metabolism. Target genes for PPARalpha include many enzymes involved in the oxidation of fatty acids in mitochondria and peroxisomes. READ MORE

  7. 5. Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I

    Author : Per J G Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; fatty acid metabolism;

    Abstract : Mouse cytosolic type I acyl-CoA thioesterase (CTE-I) is a member of the type I family of acylCoA thioesterases. These enzymes hydrolyze acyl-CoAs to non-esterified fatty acids (NEFAs) and Coenzyme A (CoA-SH) and are strongly induced in rodent liver by a diverse group of compounds called peroxisome proliferators. READ MORE