Search for dissertations about: "PRC1"
Showing result 1 - 5 of 6 swedish dissertations containing the word PRC1.
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1. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy
Abstract : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. READ MORE
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2. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression
Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE
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3. Regulation of gene expression in fruit flies : how does it start, and will it be remembered?
Abstract : One of the most distinctive features of eukaryotic chromosomes is the bundling of DNA together with functionally associated RNA and proteins in chromatin. This allows huge amounts of DNA to be packed inside the very tiny space of the nucleus, and alterations in the structure of chromatin enable access to the DNA for transcription (“reading” genes by production of RNA copies). READ MORE
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4. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation
Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE
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5. Genetic and epigenetic mechanisms underlying the regulation of flowering time
Abstract : Developmental transitions and responses to the environment have a tight epigenetic control. Especially the switch to flowering is important for plants because it allows (sexual) reproduction, and should not occur unless the conditions are right. READ MORE