Search for dissertations about: "PTEN"
Showing result 1 - 5 of 65 swedish dissertations containing the word PTEN.
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1. Genetic and Epigenetic Characterisation of Breast Tumours
Abstract : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. READ MORE
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2. Molecular Genetic Alterations In Endometrial And Ovarian Cancers
Abstract : Endometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. READ MORE
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3. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia
Abstract : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. READ MORE
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4. Insulin-like Growth Factor System: functional role and regulation in carcinomas
Abstract : The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). READ MORE
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5. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation
Abstract : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. READ MORE