Search for dissertations about: "Papain"

Showing result 1 - 5 of 10 swedish dissertations containing the word Papain.

  2. 1. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

    Author : Kristina Berggren; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; ; IdeS; SpeB; Papain; ; Conformational restriction; Peptidomimetics;

    Abstract : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. READ MORE

  4. 2. Novel Materials and Implant Designs for the Treatment of Degenerative Disc Disease

    Author : Salim Ghandour; Cecilia Persson; Donal McNally; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Topology Optimization; Spine; Intervertebral Disc; Papain; Additive Manufacturing; Biomechanics; Bone Cement; PMMA; Calcium Phosphate; Cage; Fusion; Engineering Science with specialization in Biomedical Engineering; Teknisk fysik med inriktning mot medicinsk teknik;

    Abstract : The overarching objective of this thesis was to develop intervertebral implants for degenerated discs through design, fabrication, and mechanical validation. The research had four primary aims, each addressing different facets of implant development. READ MORE

  5. 3. Structural and Functional Studies on Human Type 2 Cystatins

    Author : Marcia Alvarez Fernandez; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; structural- functional relationships.; protein crystallography; enzyme kinetics; inhibitors; cathepsins; legumains; cystatins; cysteine peptidases;

    Abstract : Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. READ MORE

  6. 4. Structural and Functional Studies of Chagasin, a Parasite Protease Inhibitor

    Author : Anna Ljunggren; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The cysteine proteases are enzymes found in every kingdom of life. Clan CA is the largest of the cysteine protease clans, with members all displaying a Cys/His/Asn(Asp) catalytic triad responsible for hydrolysing the peptide bond within the substrate. READ MORE

  7. 5. Type 2 Cystatins. Studies on the role of the major cystatin, cystatin C, in mice and on properties and distribution of the novel human cystatins F, G, H and I

    Author : Carl-Michael Nathanson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; enzyme kinetics; eosinophilic granulocytes; expression pattern; pleural effusion; knockout mouse; Cysteine peptidase; cystatin;

    Abstract : The aim the thesis work was to study the human cystatins C, E/M, F, G, H and I both in vivo and in vitro. A mouse devoid of cystatin C was used for the cystatin C studies. The levels of cystatins C, E/M and F were measured in pleural effusion samples of patients with various lung disorders. READ MORE