Search for dissertations about: "Peptide half-life"

Showing result 1 - 5 of 18 swedish dissertations containing the words Peptide half-life.

  2. 1. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

    Author : Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
    Keywords : Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

    Abstract : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. READ MORE

  4. 2. Peptide and non-peptide biomarkers of mortality in patients with advanced chronic kidney disease

    Author : Jia Sun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Over the last decade, multiple studies have attempted to identify better risk prediction tools specific to the chronic kidney disease (CKD) population. In many cases, these studies have evaluated the use of various peptide biomarkers as prediction tools. READ MORE

  5. 3. Influence of MHC class I peptide interaction on antigen presentation in normal and malignant cells

    Author : Qian-Jin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytotoxic T lymphocytes; Natural Killer cells; Epstein-Barr virus; MHC class I; class I binding motifs; T cell receptor; antigen presentation; immunodominance;

    Abstract : The presentation of MHC class I peptide complexes in normal and malignant cells was studied. An HLA A11 binding motif was defined by comparing synthetic peptide analogues of a known cytotoxic T Iymphocyte (CTL) target epitope for induction of surface A11 expression and triggering of cytotoxic activity. READ MORE

  6. 4. Development of molecular recognition by rational and combinatorial engineering

    Author : Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE

  7. 5. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands

    Author : Michael Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CD8 T cells; APL; CTLs; non-responsiveness; AICD; lck; lipid rafts; partial agonism; TCR activation.;

    Abstract : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). READ MORE