Search for dissertations about: "Peptide"

Showing result 6 - 10 of 1714 swedish dissertations containing the word Peptide.

  2. 6. Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins

    Author : Katarina Flemmer Karlsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; CD spectroscopy; peptide structure; ELISA; solid-phase peptide synthesis; peptide; P pili; chaperone; Organic chemistry; Organisk kemi;

    Abstract : Many bacteria utilize hairlike protein appendages (pili) to attach themselves to mucosal cell surfaces in the host organism. The pilus is assembled from protein subunits synthesized inside the bacteria and transported to the outer cell wall for incorporation into the growing pilus. READ MORE

  4. 7. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Author : Magnus Palmblad; Ole Nørregaard Jensen; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; Peptide; protein; peptide mass fingerprinting; identification; sequencing; protein structure; non-covalent interaction; modification; electrospray ionization; liquid chromatography; capillary electrophoresis; electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyloid β-peptide; Alzheimer’s disease.; Materialvetenskap; Materials science; Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. READ MORE

  5. 8. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors

    Author : Jonas Nilsson; Lars Baltzer; Ingemar Kvarnström; Thomas Olsson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Synthetic receptor; Peptide inhibitor conjugate; Peptide protein surface interactions; General Lead Discovery Library; Combinatorial Chemistry; Solid Phase Chemistry; Targeted Library; Thrombin inhibitor; Fluorescence; Surface Plasmon Resonance; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. READ MORE

  6. 9. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  7. 10. Structural and Functional Studies of De Novo Designed Peptides at Surfaces

    Author : Patrik Nygren; Bo Liedberg; Thomas Ederth; Martin Malmsten; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biofouling; vesicles; nanoparticles; peptide; peptide design; circular dichroism; Physical chemistry; Fysikalisk kemi;

    Abstract : The work presented in this thesis deals with the structural and functional properties of peptides at surfaces. The interaction of peptides with surfaces is an ever so common occurrence in our every day life, from the bug squashed on the windshield of our car to the barnacle on our boat, and from the blood plasma used in the hospital to the proteins in our cells. READ MORE