Search for dissertations about: "Pharmaceutical biosciences"

Showing result 1 - 5 of 43 swedish dissertations containing the words Pharmaceutical biosciences.

  2. 1. Cytochrome P450 enzymes in the biosynthesis and metabolism of bile acids and active forms of vitamin D

    Author : Zufan Araya; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Cytochrome P450 enzymes catalyzing hydroxylations in the biosynthesis and metabolism of bile acids and active forms of vitamin D3 were studied.A microsomal cytochrome P450 enzyme with a molecular mass of 53 kDa, catalyzing the 6α-hydroxylation of taurochenodeoxycholic acid was purfied from pig liver microsomes and characterized with respect to catalytic and electrophoretic properties as well as polyclonal antibodies. READ MORE

  4. 2. Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21

    Author : Johan Bylund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids. READ MORE

  5. 3. Characterization of resistance to quinolones, sulfonamide and trimethoprim in Campylobacter jejuni as well as to macrolides in the related bacterium, Helicobacter pylori

    Author : Amera Gibreel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Abstract : Gastroenteritis caused by C. jejuni is usually a mild to moderate self-limiting disease. Treatment is recommended in some cases. In recent years, quinolones have been increasingly used to treat acute bacterial enteritis. READ MORE

  6. 4. Characterization of a site-specific gene-transfer mechanism in bacteria

    Author : Karin Hansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Abstract : Integrons capture and rearrange single genes borne on mobile units called cassettes using site-specific recombination. The integrons increase the variation of antibiotic resistance among bacterial plasmids and may also reorganize clustered genes in bacterial genomes. READ MORE

  7. 5. Co-operative recombination mechanisms promoting gene clustering and lateral transfer of antibacterial drug resistance

    Author : Masood Kamali-Moghaddam; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Tn5090 Tn402; Mu-like transposons; serine recombinases; res site; integrons; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Abstract : Transposons of the Mu superfamily are widespread and have been shown to play an important role in the dissemination of antibiotic resistance among microorganisms. One of these elements, Tn5090/Tn402 is the basal vehicle of the type 1 integrons in which mobile resistance gene cassettes are inserted to form clusters and operons. READ MORE