Search for dissertations about: "Phorbol 12-myristate-13-acetate"

Showing result 1 - 5 of 11 swedish dissertations containing the words Phorbol 12-myristate-13-acetate.

  2. 1. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Author : Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Abstract : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. READ MORE

  4. 2. Signaling capacity of ß2-integrins in relations to neutrophil motility

    Author : Ragnhild Löfgren; Linköpings universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Abstract : The neutrophil granulocyte is one of the most mobile cell types in the human body and represents the first line of defense against invading pathogens. Adhesion and chemotactic receptors on the cell surface work together through modulations of the cytoskeleton and thereby cause the cell to move. READ MORE

  5. 3. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Author : Karin Gewert; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. READ MORE

  6. 4. Functional studies of T-cells in rheumatoid arthritis

    Author : Louise Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T-cells; Rheumatoid arthritis; inflammation; cytokines; collagen type II; immunomodulation;

    Abstract : Rheumatoid arthritis (RA) is a systemic inflammatory disease with autoimmune features primarily affecting the joints. The etiology of RA is largely unknown but involvement of the immune system in the disease process is evident from the infiltration of leukocytes into the joint, and by the production of proinflammatory cytokines, chemokines and proteases, mainly by macrophages. READ MORE

  7. 5. Leukotriene C4 synthesis and export in human platelets and leukocytes : LTC4 synthase expression in normal and leukemic myeloid cells

    Author : Mikael Sjölinder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotriene (LT)C4 synthase catalyses conjugation of the unstable epoxide LTA4 with reduced glutathione and is the rate-limiting enzyme in the formation of cysteinyl leukotrienes, powerful mediators of asthma and inflammation. The presence of LTC4 synthase in platelets was demonstrated by purification and characterization of bovine platelet LTC4 synthase. READ MORE