Search for dissertations about: "Pontus Hegardt"

Found 1 swedish dissertation containing the words Pontus Hegardt.

2. 1. NO, Immunosuppression and Tumor Immmunotherapy

   Author : Pontus Hegardt; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

   Abstract : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. READ MORE