Search for dissertations about: "Potential lethal damage"

Showing result 1 - 5 of 15 swedish dissertations containing the words Potential lethal damage.

  2. 1. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

    Author : Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. READ MORE

  4. 2. Superoxide dismutase : radiobiological significance : occurrence in human tissues, tumours and tumour cell-lines

    Author : Gunnar Westman; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superoxide dismutase; Radiation sensitivity; Diethyldithiocarbamate; Haemolysis; Catalase; Glutathione Peroxidase; Potential lethal damage;

    Abstract : .... READ MORE

  5. 3. Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells

    Author : J. Peter Svensson; Ingela Turesson; Jean Bourhis; Uppsala universitet; []
    Keywords : Molecular biology; gene expression profiling; DNA damage; network; cancer; ionizing radiation; cisplatin; Molekylärbiologi;

    Abstract : Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genomic DNA. As a single double strand DNA break has the potential to kill the cell, mechanisms have evolved to detect and block propagation of the damage. READ MORE

  6. 4. Bacteria and cancer : from toxin delivery to carcinogenesis

    Author : Riccardo Guidi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epidemiological evidence link certain chronic bacterial infections to a higher risk of cancer development. Induction of an inflammatory circuit and the accumulation of genomic instability are considered mechanisms by which bacteria contribute to malignant transformation. READ MORE

  7. 5. Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy

    Author : Gwladys Revêchon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aging is a complex process that occurs as we grow old and is associated with a gradual decline of tissue functions. Scientists have been trying to understand the mechanisms that drive such phenomenon by studying premature aging syndromes and aging-related disorders. READ MORE