Search for dissertations about: "Prion diseases"
Showing result 1 - 5 of 34 swedish dissertations containing the words Prion diseases.
-
1. Structural investigation of SOD1 aggregates in ALS : identification of prion strains using anti-peptide antibodies
Abstract : Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative syndrome characterized by progressive degeneration of motor neurons that result in muscle wasting. The symptoms advance gradually to paralysis and eventually death. Most patients suffer from sporadic ALS (sALS) but 10% report a familial predisposition. READ MORE
-
2. Protein Misfolding in Human Diseases
Abstract : There are several diseases well known that are due to aberrant protein folding. These types of diseases can be divided into three main categories:Loss-of-function diseasesGain-of-toxic-function diseasesInfectious misfolding diseases Most loss-of-function diseases are caused by aberrant folding of important proteins. READ MORE
-
3. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins
Abstract : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. READ MORE
-
4. Novel endogenous mechanisms of complement regulation - A delicate balance
Abstract : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. READ MORE
-
5. Molecular changes in scrapie-infected neuroblastoma cells
Abstract : .... READ MORE