Search for dissertations about: "Proof of concept"

Showing result 1 - 5 of 328 swedish dissertations containing the words Proof of concept.

  2. 1. Speaking of Geometry : A study of geometry textbooks and literature on geometry instruction for elementary and lower secondary levels in Sweden, 1905-1962, with a special focus on professional debates

    Author : Johan Prytz; Staffan Rodhe; Anders Öberg; Sten Kaijser; Jan van Maanen; Patricio Herbst; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mathematics; geometry instruction; mathematics education; Sweden; textbook; curriculum; professional; elementary school; secondary school; history of mathematics education; history of mathematics; history of education; MATEMATIK;

    Abstract : This dissertation deals with geometry instruction in Sweden in the period 1905-1962. The purpose is to investigate textbooks and other literature used by teachers in elementary schools (ES) and lower secondary schools (LSS) – Folkskolan and Realskolan – connection to geometry instruction. READ MORE

  4. 2. Concept Formation in Mathematics

    Author : Jörgen Sjögren; Högskolan i Skövde; []
    Keywords : HUMANIORA; HUMANITIES; Explication; Power of arithmetical theories; Formal proof; Informal proof; Indispensability; Mathematical realism; Naturvetenskap; Natural sciences; Explication; Power of arithmetical theories; Formal Proof; Informal proof; Indispensability; Mathematical Realism;

    Abstract : This thesis consists of three overlapping parts, where the first one centers around the possibility of defining a measure of the power of arithmetical theories. In this part a partial measure of the power of arithmetical theories is constructed, where “power” is understood as capability to prove theorems. READ MORE

  5. 3. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

    Author : Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

    Abstract : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. READ MORE

  6. 4. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

    Author : Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Abstract : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. READ MORE

  7. 5. Model-Based Optimization of Clinical Trial Designs

    Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE