Search for dissertations about: "Protein Folding"

Showing result 1 - 5 of 131 swedish dissertations containing the words Protein Folding.

  1. 1. Protein folding without loops and charges

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Martin Kurnik; Stockholms universitet.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; folding cooperativity; protein aggregation; protein charges; protein engineering; biokemi; Biochemistry;

    Abstract : Going down the folding funnel, proteins may sample a wide variety of conformations, some being outright detrimental to the organism. Yet, the vast majority of polypeptide molecules avoid such pitfalls. Not only do they reach the native minimum of the energy landscape; they do so via blazingly fast, biased, routes. READ MORE

  2. 2. The birth and growth of the protein folding nucleus Studies of protein folding focused on critical contacts, topology and ionic interactions

    University dissertation from Stockholm : Institutionen för biokemi och biofysik

    Author : Linda Hedberg; Stockholms universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; chevron plot; transition-state movements; Hammond behaviour; topology; electrostatic interactions; pH dependence; mass-action; protein engineering; pKa; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. READ MORE

  3. 3. Folding of the Ribosomal protein S6 The role of sequence connectivity, overlapping foldons, and parallel pathways

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Ellinor Haglund; Stockholms universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. READ MORE

  4. 4. Structure determination and thermodynamic stabilization of an engineered protein-protein complex

    University dissertation from Stockholm : KTH

    Author : Elisabet Wahlberg; KTH.; [2006]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; protein structure; coupled folding; NMR spectroscopy; protein stability; protein-protein interactions; binding thermodynamics; isothermal titration calorimetry; protein engineering; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Abstract : The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. READ MORE

  5. 5. Physical Modeling of Protein Folding

    University dissertation from Department of Theoretical Physics, Lund University

    Author : Stefan Wallin; Lunds universitet.; Lund University.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; relativity; quantum mechanics; classical mechanics; three-helix bundle; similarity measure; Mathematical and general theoretical physics; protein dynamics; protein folding; two-state; Matematisk och allmän teoretisk fysik; thermodynamics; statistical physics; gravitation; klassisk mekanik; kvantmekanik; relativitet; statistisk fysik; termodynamik; Fysicumarkivet A:2003:Wallin;

    Abstract : Popular Abstract in Swedish Sekvensbaserade proteinveckningsmodeller utvecklas och testas på peptider med både betablad- och alfahelix-struktur, samt på små helix-proteiner. Modellernas potentialer är minimalistiska och baseras huvudsakligen på vätebindningar och effektiva hydrofobicitetskrafter. READ MORE