Search for dissertations about: "Protein aggregate"

Showing result 1 - 5 of 88 swedish dissertations containing the words Protein aggregate.

  2. 1. Properties of Protein and Polymer Systems

    Author : Fredrik Carlsson; Avdelningen för Konstruktionsteknik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Physical chemistry; lysozyme; mica; surface; dimerization; precipitation; aggregate; cluster; complex; polyelectrolyte; protein; polymer;

    Abstract : Interactions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these systems. READ MORE

  4. 2. On the role of actin in yeast protein quality control

    Author : Lisa Larsson Berglund; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein quality control; Actin; Protein aggregate; Segregation; Polarisome; CCT; Huntingtin;

    Abstract : Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. READ MORE

  5. 3. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Author : Irem Nasir; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Abstract : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. READ MORE

  6. 4. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

    Author : Julia Scheffel; Sophia Hober; Alois Jungbauer; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibodies; Antibody fragments; Biomanufacturing; Protein purification; Protein engineering; Protein A; ZCa; Calcium; Mild elution; Bioteknologi; Biotechnology;

    Abstract : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. READ MORE

  7. 5. Stress response regulation and protein aggregate inheritance in Caulobacter crescentus

    Author : Frederic Dominique Schramm; Kristina Jonas; Franz Narberhaus; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; stress; protein aggregation; cellular aging; molecular chaperones; heat shock response; DnaK; sigma factor; suppressor genes; DNA replication; starvation; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Many stress conditions a cell encounters threaten the continuation of basic biological processes ultimately endangering its survival. Heat shock and antibiotic exposure can lead to a sudden surge of protein un- and misfolding, while nutrient starvation directly causes a lack of energy and molecular building blocks. READ MORE