Search for dissertations about: "Proteomics SELDI"

Showing result 1 - 5 of 13 swedish dissertations containing the words Proteomics SELDI.

  2. 1. A multivariate approach to computational molecular biology

    Author : Fredrik Pettersson; Michael Sjöström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; biomarker; Drosophila; SNP; linkage; disequilibrium; bioinformatics; computational; molecular; biology; genomics; microarray; SELDI; proteomics; Bioinformatics; Bioinformatik;

    Abstract : This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. READ MORE

  4. 2. Metabolomics and proteomics studies of brain tumors : a chemometric bioinformatics approach

    Author : Lina Mörén; Henrik Antti; Anders Malmendal; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; glioma; meningioma; metabolomics; proteomics; mass-spectrometry; biologisk kemi; biological chemistry;

    Abstract : The WHO classification of brain tumors is based on histological features and the aggressiveness of the tumor is classified from grade I to IV, where grade IV is the most aggressive. Today, the correlation between prognosis and tumor grade is the most important component in tumor classification. READ MORE

  5. 3. Protein Profiling and Type 2 Diabetes

    Author : Tea Sundsten; Peter Bergsten; Leif Jansson; Maria Sörhede Winzell; Uppsala universitet; []
    Keywords : Cell biology; Type 2 diabetes; Protein profiling; SELDI-TOF MS; Proteomics; Cellbiologi;

    Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease affecting millions of people worldwide. Both genetic and environmental factors contribute to the pathogenesis. The disease is characterized by alterations in many genes and their products. READ MORE

  6. 4. Helicobacter pylori cell surface interactions with glycosaminoglycans. Identification and characterisation of proteins binding to heparin/heparan sulphate

    Author : Meeme Utt; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SELDI-TOF MS; bioinformatics; proteomics; immunoblotting; 2-DE; biosensor; heparan sulphate; heparin; binding; Helicobacter pylori; cell surface; bakteriologi; Mikrobiologi; mycology; bacteriology; Microbiology; mykologi; virologi; virology;

    Abstract : Helicobacter pylori is a gastric pathogen which cause chronic type B gastritis and peptic ulcer disease. H. pylori produces virulence factors such as urease, vacuolating cytotoxin VacA, cag pathogenicity island-associated proteins, flagella and adhesins. READ MORE

  7. 5. Glucotoxicity in Insulin-Producing β-Cells

    Author : Hanna K Nyblom; Peter Bergsten; Michael Welsh; Miriam Cnop; Uppsala universitet; []
    Keywords : Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

    Abstract : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. READ MORE