Search for dissertations about: "PrtV"

Showing result 1 - 5 of 7 swedish dissertations containing the word PrtV.

2. 1. Structural and functional studies of the secreted metalloprotease PrtV from Vibrio cholerae

   Author : Aaron Edwin; Elisabeth Sauer-Eriksson; Helena Berglund; Umeå universitet; []
   Keywords : Cholera; Vibrio cholerae; virulence factors; PrtV; X-ray crystallography; NMR;

   Abstract : Cholera, an acute diarrheal diseases caused by the intestinal infection of the pathogenic bacterium Vibrio cholerae, continues to be a global killer in the world today. PrtV, a secreted zinc metalloprotease, is a potent cytotoxic virulence factor of V. cholerae. READ MORE

4. 2. Modulators of Vibrio cholerae predator interaction and virulence

   Author : Barbro Lindmark; Sun Nyunt Wai; Kristian Riesbeck; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; Caenorhabditis elegans; PrtV; outer membrane vesicles; non-O1 non-O139; serum resistance; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Vibrio cholerae, the causal agent of cholera typically encodes two critical virulence factors: cholera toxin (CT), which is primarily responsible for the diarrhoeal purge, and toxin-co-regulated pilus (TCP), an essential colonisation factor. Nontoxigenic strains expressing TCP can efficiently acquire the CT gene through lysogenic conversion with CTXΦ, a filamentous phage that encodes CT and uses TCP as a receptor. READ MORE

5. 3. Outer membrane vesicle-mediated export of virulence factors from Gram-negative bacteria

   Author : Pramod Kumar Rompikuntal; Sun Nyunt Wai; Ann-Beth Jonsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Outer membrane vesicles; CDT; PGN; PrtV; Campylobacter jejuni; Vibrio cholerae; Aggregatibacter actinomycetemcomitans; molekylärbiologi; Molecular Biology;

   Abstract : The Gram-negative, motile bacterium Campylobacter jejuni is a causative agent of food-borne gastroenteritis. Cytolethal distending toxin (CDT) is one of the important virulence factors for C. jejuni pathogenesis. It was not previously known how CDT is released from C. READ MORE

6. 4. Vibrio cholerae modulates the immune defense of human gut mucosa

   Author : Aziz Bitar; Marie-Louise Hammarström; Sun Nynt Wai; Mikael Rehn; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; intestinal epithelial cell; duodenum biopsy; acute cholera; immunomodulation; microRNA; OMV; cytokine; T84 monolayer; miR-146; miR-155; VCC; PrtV; hemolysis; IL-8; TNF-a; IL-1b; IL-18; CCL20; IRAK2; inflammation; mikrobiologi; Microbiology; immunologi; Immunology;

   Abstract : The key function of innate immunity is to sense danger signals and initiate effective responses as a defense mechanism against pathogens. Simultaneously, effector responses must be regulated to avoid excessive inflammation with resulting tissue damage. READ MORE

7. 5. Roles of membrane vesicles in bacterial pathogenesis

   Author : Svitlana Vdovikova; Sun Nyunt Wai; Richard Lundmark; Ann-Beth Jonsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane vesicles; autophagy; pore-forming toxin; pore formation; Listeria monocytogenes; Vibrio cholerae; virulence factor; PrtV protease; listeriolysin O; V. cholerae cytolysin; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology;

   Abstract : The production of membranous vesicles is observed to occur among organisms from all domains of the tree of life spanning prokaryotes (bacteria, archaea) and eukaryotes (plants, animals and fungi). Bacterial release of membrane-derived vesicles (MVs) has been studied most extensively in cases of Gram-negative species and implicating their outer membrane in formation of extracellular MVs. READ MORE