Search for dissertations about: "Quinolones"
Showing result 1 - 5 of 18 swedish dissertations containing the word Quinolones.
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1. Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms
Abstract : Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, plasmid-mediated resistance genes, such as qnr, often confer moderate levels of resistance. READ MORE
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2. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions : Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors
Abstract : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. READ MORE
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3. Characterization of resistance to quinolones, sulfonamide and trimethoprim in Campylobacter jejuni as well as to macrolides in the related bacterium, Helicobacter pylori
Abstract : Gastroenteritis caused by C. jejuni is usually a mild to moderate self-limiting disease. Treatment is recommended in some cases. In recent years, quinolones have been increasingly used to treat acute bacterial enteritis. READ MORE
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4. Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens
Abstract : Opportunistic pathogens can cause infections in case of structural or functional defects in the host. Examples of Gram-negative opportunists are the Bacteroides fragilis group, anaerobic, non-spore forming rods and the aerobic, non-fermentative rod Pseudomonas aeruginosa. READ MORE
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5. The GABAA Receptor as Target for Novel Heterocyclic Compounds
Abstract : Ligands for the benzodiazepine-binding site of the GABAA receptor can belong to structurally diverse classes of compounds including, in spite of the name of the binding site, many non-benzodiazepine structures. The GABAA receptor is a ligand-gated ion channel assembled of five subunits from eight different classes with multiple isoforms. READ MORE