Search for dissertations about: "R5 envelope HIV-1 evolution"

Found 5 swedish dissertations containing the words R5 envelope HIV-1 evolution.

  2. 1. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins

    Author : Johanna Repits; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; envelope; R5; HIV-1; evolution;

    Abstract : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. READ MORE

  4. 2. Intrahost evolution of HIV-1 phenotypes

    Author : Marie Borggren; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : HIV-1 evolves constantly within an infected individual, due to its mutation-prone viral enzyme, high viral turnover and pressure from the host immune system. Therefore, viruses isolated at different time points from the same individual are never exactly the same and, accordingly, rarely function the same way. READ MORE

  5. 3. Intrapatient evolution of HIV-1 in the context of coreceptor usage

    Author : Mattias Mild; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coreceptor switch; Medicine human and vertebrates ; Medicin människa och djur ; biological cloning; R5-X4; coreceptor usage; glycosylation; recombination; HIV; evolution;

    Abstract : The variable region 1 to 3 (V1-V3) of the HIV-1 envelope plays an important role in coreceptor usage. Early in infection HIV- 1 is using CCR5 as coreceptor to enter target cells (R5 viruses) whereas viruses using CXCR4 as coreceptor (X4 viruses) may appear later in infection. READ MORE

  6. 4. Phylogenetic and phenotypic properties of HIV-1 variants of different subtypes, in mother to child transmission

    Author : Rozina Caridha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transmission from mother to child is the most common way that children contract HIV-1 infection in developing countries; transmission through this route is prevented in most developed countries by antiretroviral treatment, elective Caesarean section and absence of breast-feeding. However, these measures are not fully available in developing countries. READ MORE

  7. 5. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

    Author : Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

    Abstract : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. READ MORE